Anti-latency agents to purge HIV reservoirs
نویسندگان
چکیده
منابع مشابه
HIV-1 Reservoirs and Latency: Critical Barriers and Clues for HIV / AIDS Cure
Human immunodeficiency virus type 1 (HIV-1) infection is still a formidable threat to public health in spite of remarkable therapeutic advances (Adoga et al., 2009; Goselle, 2011). Highly active antiretroviral therapy (HAART) is effective against HIV/AIDS but it is not curative, and hence does not lead to the eradication of HIV-1 infection. Patients on HAART usually have their HIV RNA levels su...
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The urgent need for new anti-HIV/AIDS drugs is a global concern. In addition to obvious economical and commercial hurdles, HIV/AIDS patients are faced with multifarious difficulties associated with the currently approved anti-HIV drugs. Adverse effects, the emergence of drug resistance and the narrow spectrum of activity have limited the therapeutic usefulness of the various reverse transcripta...
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Background Even though, Highly Active Antiretroviral Therapy (HAART) has resulted in significant reduction in mortality associated with Acquired Immune Deficiency Syndrome (AIDS), the side-effects and difficulties in patient compliance warrants the search for new therapeutic options. One potential strategy is to design chemokine analogues that will prevent the entry of human immunodeficiency vi...
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Novel targets for the management of HIV infection have become increasingly relevant in view of extensive drug resistance, side effects and high pill burden of some of the conventional anti-retroviral agents. These agents include chemokine receptor antagonists and the integrase inhibitors which were recently approved for HIV treatment, as well as numerous other agents directed to previously unte...
متن کاملHow to best measure HIV reservoirs?
PURPOSE OF REVIEW The persistence of HIV within infected CD4 T cells is a major obstacle to eradication, and assessment of the strategies to reduce HIV reservoirs is one of the major challenges. Measuring HIV reservoirs accurately will be necessary to assess those strategies. The objective of this review is to present the most recent studies that may help to define the best markers to measure H...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2012
ISSN: 1742-4690
DOI: 10.1186/1742-4690-9-s1-i16